Small-cell variant of ALK+ anaplastic large-cell lymphoma with a leukemic phase.
نویسندگان
چکیده
T his peripheral blood (PB) smear from a 24-year-old man with retroperitoneal lymphadenopathy and a white blood cell count of 77 3 10 cells/L (66% lymphocytes) showed variably-sized atypical lymphocytes with irregular nuclear contours and basophilic vacuolated cytoplasm including numerous flower cells and apoptotic cells (panel A). Hallmark cells with reniform nuclei, small to large in size, were a minor proportion (panels A and B). Flow cytometric analysis (FC) of the PB and bone marrow (BM) samples detected a T-cell population with low forward scatter and CD2(dim), CD3(dim), CD7, CD8(dim), CD4, CD5, and CD25; CD30 expression was dim in the BM and negative in the PB by FC. BM morphology showed scattered interstitial infiltration of smallto medium-sized atypical lymphocytes that were variably CD30 and ALK (nuclear staining) by immunohistochemistry (panel B). BM fluorescence in situ hybridization and karyotype studies revealed ALK rearrangement and t(2;5)(p23;q35), respectively.
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عنوان ژورنال:
- Blood
دوره 124 20 شماره
صفحات -
تاریخ انتشار 2014